Response to Comment on "Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing"

Wang question whether Lamin B receptor is required for Xist-mediated silencing because they claim that our cells contain an inversion rather than a deletion. We present evidence that these cells contain a proper deletion and that the confusion is caused by DNA probes used in the experiment. Accordin...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 356; no. 6343
Main Authors Chen, Chun-Kan, Chow, Amy, Lai, Mason, Guttman, Mitchell
Format Journal Article
LanguageEnglish
Published United States 16.06.2017
Subjects
Gene Silencing
Humans
Nuclear Lamina
RNA, Long Noncoding - genetics
RNA, Untranslated - genetics
X Chromosome
X Chromosome Inactivation
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Summary:Wang question whether Lamin B receptor is required for Xist-mediated silencing because they claim that our cells contain an inversion rather than a deletion. We present evidence that these cells contain a proper deletion and that the confusion is caused by DNA probes used in the experiment. Accordingly, the points raised have no effect on the conclusions in our paper.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aam5439