New 2-pyrone-based hydrazones: Synthesis, spectral characterisation, UV-visible study and evaluation of the antiradicalar activity

The synthesis of new 2-pyrone-based hydrazones has been prepared by the coupling of 6-methyl-2H-furo[3,2-c]pyran-3,4-dione with diazonium salts, obtained by diazotization of aniline derivatives. The structure of all compounds was established by spectroscopic methods, and the structure of the more st...

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Published inSynthetic communications Vol. 47; no. 6; pp. 590 - 598
Main Authors Oukacha-Hikem, Djamila, Makhloufi-Chebli, Malika, Amar, Anissa, Bouherrou, Houria, Rachedi, Yahia, Meghezzi, Hacène, Silva, Artur M. S., Hamdi, Maamar
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis 19.03.2017
Taylor & Francis Ltd
Subjects
Antiradicalar activity
Chemistry
Chemistry, Organic
diazonium salts
hydrazones
Physical Sciences
pyran-2-ones
Science & Technology
theoretical calculations
Antiradicalar activity
diazonium salts
pyran-2-ones
theoretical calculations
ANALOGS
ANTIBACTERIAL
PYRONES
hydrazones
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Summary:The synthesis of new 2-pyrone-based hydrazones has been prepared by the coupling of 6-methyl-2H-furo[3,2-c]pyran-3,4-dione with diazonium salts, obtained by diazotization of aniline derivatives. The structure of all compounds was established by spectroscopic methods, and the structure of the more stable conformer was theoretically confirmed by the potential energy profile analysis. The prepared 2-pyrone-based hydrazone dyes were acetylated and both groups of compounds showed moderate to good radical scavenging activity.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2016.1276602