PAM variants were associated with type 2 diabetes mellitus risk in the Chinese population

• Published in: Functional & integrative genomics Vol. 22; no. 4; pp. 525 - 535
• Main Authors: Sheng, Binwu, Wei, Huiyi, Li, Zhiying, Wei, Haoyang, Zhao, Qingbin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2022; Springer Nature B.V
• Subjects: Animal Genetics and Genomics; Biochemistry; Bioinformatics; Biomedical and Life Sciences; Body mass index; Cell Biology; Diabetes; Diabetes mellitus (non-insulin dependent); Fasting; Genomes; Genomics; genotype; Genotype & phenotype; Glucose; Hospitals; Life Sciences; Metabolism; Microbial Genetics and Genomics; noninsulin-dependent diabetes mellitus; Original Article; pathogenesis; people; Peptides; Plant Genetics and Genomics; Population; Population studies; Regression analysis; retinal diseases; Retinopathy; risk; Single-nucleotide polymorphism; Software; Variants; The Chinese population; Type 2 diabetes mellitus; PAM
• ISSN: 1438-793X; 1438-7948; 1438-7948
• DOI: 10.1007/s10142-022-00840-0

This study aimed to assess the association between PAM single-nucleotide polymorphisms (SNPs) and T2DM risk in the Chinese population. We performed the genotype of PAM SNPs using Agena MassARRAY in 1002 subjects. The effect of PAM polymorphisms on T2DM occurrence was evaluated by logistic regression analysis. False-positive report probability (FPRP) was utilized to assess the noteworthiness of the significant results. This study showed that PAM rs406761, rs17154889, and rs6889592 were related to an increased risk of T2DM. The similar results were also in subjects with ≤ 60 years. Rs2431320 and rs406761 were related to an increased risk of T2DM in males, and rs6889592 was only found to be associated with T2DM risk in females. Rs2431320 and rs406761 increased T2DM risk in people with BMI > 24, and rs6889592 and rs26431 significantly correlated with T2DM risk in people with BMI ≤ 24. By comparing patients with no retinopathy with controls, the correlation between PAM rs406761 and rs17154889 and T2DM risk was observed. The significant association between T2DM risk and PAM SNPs was remarkable by FPRP values. PAM SNPs were correlated with T2DM risk in the Chinese population, illustrating the importance of PAM SNPs in the pathogenesis of T2DM.