Preparation of biocompatible microsphere-cryogel composite system and controlled release of mupirocin

In this study, polyvinylpyrrolidone/sodium carboxymethyl cellulose (PVP/NaCMC) microspheres containing an antibiotic agent Mupirocin (MP) were prepared. The effect of polymer/polymer ratio, cross-linking time and drug/polymer (d/p) ratio was investigated on MP release. The best condition for the rel...

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Bibliographic Details
Published inInternational journal of polymeric materials Vol. 73; no. 5; pp. 354 - 361
Main Authors Yavuz, Burcu, Kondolot Solak, Ebru, Oktar, Ceren
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 23.03.2024
Taylor & Francis Ltd
Subjects
Biocompatibility
Biopolymers
Carboxymethyl cellulose
Controlled release
Crosslinking
cryogel
Disks
drug release
Microspheres
mupirocin
Polyhydroxyethyl methacrylate
Polymers
Polyvinylpyrrolidone
Sodium carboxymethyl cellulose
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Summary:In this study, polyvinylpyrrolidone/sodium carboxymethyl cellulose (PVP/NaCMC) microspheres containing an antibiotic agent Mupirocin (MP) were prepared. The effect of polymer/polymer ratio, cross-linking time and drug/polymer (d/p) ratio was investigated on MP release. The best condition for the release of MP was found to be 79.2%. Polyhydroxy methacrylate (pHEMA) based microsphere-cryogel composite system was prepared in a disk form using microspheres with the best drug release profile. Surface and bulk structures of cryogel disks were identified with scanning electron microscopy (SEM). The best MP release was found in 82.7% of the microsphere-cryogel composite system.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2022.2163638