Development of Ga-68 radiolabeled DOTA functionalized and acetylated PAMAM dendrimer-coated iron oxide nanoparticles as PET/MR dual-modal imaging agent

Gallium-68 radiolabeled DOTA- acetyl-PAMAM coated iron oxide nanoparticles (NPs) were developed as dual-modality agents for PET-MR imaging. The increase in the chelator content, acetylation step, and radiolabeling condition had distinctive effects on the physical, biological, and radiochemical prope...

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Published inInternational journal of polymeric materials Vol. 70; no. 15; pp. 1077 - 1089
Main Authors Almasi, Tinoosh, Gholipour, Nazila, Akhlaghi, Mehdi, Mokhtari Kheirabadi, Amin, Mazidi, Seyed Mohammad, Hosseini, Seyed Hassan, Geramifar, Parham, Beiki, Davood, Rostampour, Nima, Shahbazi Gahrouei, Daryoush
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 13.10.2021
Taylor & Francis Ltd
Subjects
Acetylation
Biological properties
Computed tomography
Gallium
Gallium-68
iron oxide nanoparticles
Iron oxides
Magnetic resonance imaging
Medical imaging
Nanoparticles
PET/MR imaging agent
poly(amidoamide) dendrimer
Positron emission
Radiochemistry
radiolabeling
Radiolabelling
Spleen
Tomography
Tumors
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Summary:Gallium-68 radiolabeled DOTA- acetyl-PAMAM coated iron oxide nanoparticles (NPs) were developed as dual-modality agents for PET-MR imaging. The increase in the chelator content, acetylation step, and radiolabeling condition had distinctive effects on the physical, biological, and radiochemical properties of NPs. The r2 relaxivity coefficient value of the NPs was 96.7 mM −1 s −1 . High accumulation of candidate NPs was in the liver and spleen and about 3.4% ID/g uptake (tissue sampling), and a distinctive uptake (PET-CT image) were observed in the tumor site. These NPs could be used as the dual-modality agent for the diagnosis of the tumors via PET-MR imaging.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2020.1785451