Review of the aldol reaction

• Published in: Synthetic communications Vol. 46; no. 16; pp. 1327 - 1342
• Main Authors: Mandal, Swagata, Mandal, Sangita, Ghosh, Sumanta K., Ghosh, Aniruddha, Saha, Rumpa, Banerjee, Soujanya, Saha, Bidyut
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 17.08.2016; Taylor & Francis Ltd
• Subjects: Aldol condensation; catalytic antibodies; nano reactors; organocatalysis
• ISSN: 0039-7911; 1532-2432
• DOI: 10.1080/00397911.2016.1206938

Aldol condensation is an important synthetic method widely used in organic synthesis. Development of catalytic methods that avoids the production of stoichiometric by-products while maintaining high levels of control available from stoichiometric processes provides an atom-economical alternative for these important transformations. Indeed, numerous catalysts for the aldol reaction have been reported in recent years, including enzymes, catalytic antibodies, organometals, organocatalysts, and small molecules. The direct aldol reaction is the most important reaction employed by synthetic chemists and is common in nature. Recently, various Lewis acids have been examined as catalysts for aldol reactions, but aldol condensation in a micellar medium has not been studied in detail so far. Because of stronger environmental concerns, organic reactions in green media, especially in water, have attracted more attention. It is believed that micelles act as nano reactors to enhance the reaction rates and give very good to excellent yields of end products.