Fluorescent Determination of Glucose in Human Perspiration Using a Sensing Platform Composed of CdTe Quantum Dots (QDs) with a Zeolitic Imidazolate Framework (ZIF-8) (QD@ZIF-8)

• Published in: Analytical letters Vol. 57; no. 18; pp. 3079 - 3087
• Main Authors: Lei, Kang, Wang, Ke
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis 11.12.2024; Taylor & Francis Ltd
• Subjects: Biomarkers; Body fluids; Cadmium tellurides; CdTe quantum dots (QDs); Condition monitoring; Fluorescence; Glucose; glucose determination; human perspiration; Injury analysis; Injury prevention; metal-organic framework (MOF); Metal-organic frameworks; Perspiration; Quantum dots; Room temperature; Sweating; Thermal stability; Transition layers; Zeolites; zeolitic imidazolate framework (ZIF-8)
• ISSN: 0003-2719; 1532-236X
• DOI: 10.1080/00032719.2024.2310624

In sports, noninvasive analysis and monitoring of the human health condition are important to ensure the well-being of the sportsperson and prevent injuries. Multiple biomarker-related substances in body fluids can serve as physiological information and health or health status indicators to detect possible dangers to the athlete. As the glucose content in perspiration may vary with gender and the parts of the body, it is important to develop a highly sensitive and selective glucose detection method. Here, CdTe quantum dots (QDs) are wrapped with a zeolitic imidazolate framework (ZIF-8) to create a fluorescence sensor platform (QD@ZIF-8), which is successfully employed for the determination of glucose levels in human perspiration. The synthesis of QD@ZIF-8 is quickly and easily achieved at room temperature through a one-step process. The resulting platform exhibits strong fluorescence, emitting at a wavelength of 587 nm when excited at 360 nm. The application of ZIF-8 as a transition layer to envelope the CdTe QDs effectively provide chemical and thermal stability, excellent dispersibility, and size selectivity. The sensor is utilized to measure perspiration glucose levels in a diverse group of male and female subjects, revealing significant differences in perspiration glucose concentrations.