Linkage between loci of quantitative traits and marker loci: multi-trait analysis with a single marker

• Published in: Theoretical and applied genetics Vol. 90; no. 6; pp. 776 - 786
• Main Authors: Ronin, Y.I, Kirzhner, V.M, Korol, A.B
• Format: Journal Article
• Language: English
• Published: Germany 01.05.1995
• Subjects: backcrossing; correlated traits; genetic markers; inbred lines; linkage (genetics); loci; mathematical models; maximum likelihood; Monte Carlo method; quantitative genetics; quantitative traits; recombinant inbred lines
• ISSN: 0040-5752; 1432-2242
• DOI: 10.1007/BF00222012

An efficient approach to increase the resolution power of linkage analysis between a quantitative trait locus (QTL) and a marker is described in this paper. It is based on a counting of the correlations between the QTs of interest. Such correlations may be caused by the segregation of other genes, environmental effects and physiological limitations. Let a QT locus A/a affect two correlated traits, x and y. Then, within the framework of mixture models, the accuracy of the parameter estimates may be seriously increased, if bivariate densities faa(x,y), fAa(x,y) and fAA(x,y) rather than the marginals are considered as the basis for mixture decomposition. The efficiency of the proposed method was demonstrated employing Monte-Carlo simulations. Several types of progeny were considered, including backcross, F2 and recombinant inbred lines. It was shown that provided the correlation between the traits involved was high enough, a good resolution to the problem is possible even if the QTL groups are strongly overlapping for their marginal densities.