The inhibitory effects of endogenous NADPH-pyrophosphatase on the reduction of cytochrome c and the oxidation of drugs by liver microsomes

NADPH-pyrophosphatase in rat liver converts NADPH to products which inhibit NADPH cytochrome c reductase. This reaction obscures studies on the K m (NADPH) for drug oxidation by liver microsomes from this species. Studies with mouse liver microsomes, which contain relatively little NADPH-pyrophospha...

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Bibliographic Details
Published inArchives of biochemistry and biophysics Vol. 140; no. 1; pp. 113 - 121
Main Authors Sasame, Henry A., Gillette, James R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.1970
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