Biogenetic-type Synthesis of 2-Hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone, a Modified Apocarotenoid from Ipomoea pes-caprae

A biogenetic-type synthesis of 2-hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone (1), a modified apocarotenoid isolated from Ipomoea pes-caprae (Linn.) R. Br. showing anti-inflammatory activity by inhibiting prostaglandin synthesis in vitro, is described. A biogenetic proposal for the natural occurrence...

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Published inNatural product communications Vol. 7; no. 7; pp. 827 - 830
Main Authors Fondekar, Kamalesh P. Pai, Paknikar, Shashikumar K., Torres, Savia, Kamat, Shrivallabh P.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.07.2012
Subjects
Anti-Inflammatory Agents - chemical synthesis
Anti-Inflammatory Agents - chemistry
Carotenoids - chemistry
Ipomoea - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Extracts - chemistry
2-Hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone
Ipomoea pes-caprae
Apocarotenoid
α- and β-Ionones
Diosphenol
β-Carotene
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Summary:A biogenetic-type synthesis of 2-hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone (1), a modified apocarotenoid isolated from Ipomoea pes-caprae (Linn.) R. Br. showing anti-inflammatory activity by inhibiting prostaglandin synthesis in vitro, is described. A biogenetic proposal for the natural occurrence of 1 is also presented.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1200700705