Improved protein resistance of silicone hydrogels by grafting short peptides for ophthalmological application

A simple and facile approach to impart the antifouling properties of silicone hydrogels was developed in this report. Short peptides were first tethered to silicone hydrogels through terminal amino group-induced epoxy ring-opening click reaction. The modified silicone hydrogels have improved hydroph...

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Bibliographic Details
Published inInternational journal of polymeric materials Vol. 66; no. 12; pp. 618 - 625
Main Authors Xu, Chen, He, Ruiyu, Xie, Binbin, Ismail, Muhammad, Yao, Chen, Luan, Jie, Li, Xinsong
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 13.08.2017
Taylor & Francis Ltd
Subjects
Antifouling
contact lens
Contact lenses
grafting
Hydrogels
Ophthalmology
Peptides
Protein adsorption
Proteins
short peptide
silicone hydrogel
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Summary:A simple and facile approach to impart the antifouling properties of silicone hydrogels was developed in this report. Short peptides were first tethered to silicone hydrogels through terminal amino group-induced epoxy ring-opening click reaction. The modified silicone hydrogels have improved hydrophilicity and protein adsorption resistance because of the formation of zwitterionic structure of the grafted peptides. Furthermore, glycylglycine and diglycyl glycine-modified silicone hydrogel contact lenses were fabricated. They exhibited favorable antifouling property and no damage to rabbits' eyes after continuous wearing. The short peptide modified silicone hydrogel contact lenses have potential application in ophthalmology.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2016.1252356