Preparation of curcumin-loaded pluronic F127/chitosan nanoparticles for cancer therapy

Nanoparticles (NPs) have been proven to be an effective delivery system with few side effects for anticancer drugs. In this study, curcumin-loaded NPs have been prepared by an ionic gelation method using chitosan (Chi) and pluronic®F-127 (PF) as carriers to deliver curcumin to the target cancer cell...

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Published inAdvances in natural sciences. Nanoscience and nanotechnology Vol. 4; no. 2; pp. 25001 - 25004
Main Authors Phuc Le, Thi Minh, Pham, Van Phuc, Lua Dang, Thi Minh, Huyen La, Thi, Le, Thi Hanh, Le, Quang Huan
Format Journal Article
LanguageEnglish
Published IOP Publishing 25.03.2013
Subjects
chitosan
curcumin
ionic gelation
pluronic
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Summary:Nanoparticles (NPs) have been proven to be an effective delivery system with few side effects for anticancer drugs. In this study, curcumin-loaded NPs have been prepared by an ionic gelation method using chitosan (Chi) and pluronic®F-127 (PF) as carriers to deliver curcumin to the target cancer cells. Prepared NPs were characterized using Zetasizer, fluorescence microscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Our results showed that the encapsulation efficiency of curcumin was approximately 50%. The average size of curcumin-loaded PF/Chi NPs was 150.9 nm, while the zeta potential was 5.09 mV. Cellular uptake of curcumin-loaded NPs into HEK293 cells was confirmed by fluorescence microscopy.
ISSN:2043-6262
2043-6254
2043-6262
DOI:10.1088/2043-6262/4/2/025001