Garlic oil loaded rosuvastatin solid self-nanoemulsifying drug delivery system to improve level of high-density lipoprotein for ameliorating hypertriglyceridemia
Objective of study was to develop a solid self-nanoemulsifying rosuvastatin drug delivery system (S-SNEDDS) for enhancement of its oral bioavailability and to produce synergistic action with garlic oil for better management of hypertriglyceridemia. Results showed that mean globule size of all recons...
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Published in | Particulate science and technology Vol. 40; no. 2; pp. 165 - 181 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Philadelphia
Taylor & Francis
17.02.2022
Taylor & Francis Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | Objective of study was to develop a solid self-nanoemulsifying rosuvastatin drug delivery system (S-SNEDDS) for enhancement of its oral bioavailability and to produce synergistic action with garlic oil for better management of hypertriglyceridemia. Results showed that mean globule size of all reconstituted self-nanoemulsifying drug delivery system (SNEDDS) was found to be in nanometric range (48.32-73.64 nm) with optimum polydispersibility index (PDI) values (0.215-0.448). Rosuvastatin release from SNEDDS formulae in vitro showed that more than 75% of rosuvastatin released in about 30 min. Optimized SNEDDS formulae were selected for use with spray drying technique to develop into S-SNEDDS. Rosuvastatin plasma concentrations in rats treated with S-SNEDDS have been found at all times to be substantially high. When garlic oil-loaded rosuvastatin S-SNEDDS was administered orally to poloxamer-407 (P-407) induced hypertriglyceridemia rats there was significant (p ˂ 0.01) more increase in high-density lipoprotein (HDL) (19.24 ± 0.40 mg/dl) in comparision to rosuvastatin commercial tablet treated group. Rosuvastatin commercial tablet treated group showed significantly (p ˂ 0.01) less PT and APTT as compared to garlic oil loaded rosuvastatin S-SNEDDS treated group. Findings showed that garlic oil loaded rosuvastatin S-SNEDDS might play important role in better management of hypertriglyceridemia. |
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ISSN: | 0272-6351 1548-0046 |
DOI: | 10.1080/02726351.2021.1929604 |