Synthesis of N-Acyl Triazolyl-Pyrazolines via Acylation Initiated by the Hydrazone Moiety with Carboxylic Acids

An efficient synthesis of N-acyl/N-substituted acyl pyrazolines and their triazole hybrids have been accomplished via acylation of pyrazolines and pyrazoline-triazole hybrids with carboxylic acids and/or substituted carboxylic acids in the absence of activating agents/catalysts. In the present study...

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Published inSynthetic communications Vol. 45; no. 23; pp. 2748 - 2763
Main Authors Sivasubramaniyan, Archana, Murugan, Dinesh, Raja, Ranganathan, Murugan, Sathishkumar, Poovan, Shanmugavelan, Alagusundaram, Ponnuswamy
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis 02.12.2015
Taylor & Francis Ltd
Subjects
Acids
Acylation
Atmospheric aerosols
Chemistry
Chemistry, Organic
hybrids
hydrazones
Physical Sciences
pyrazolines
Science & Technology
triazole
SOLVENT-FREE CONDITIONS
ACETYLATION
pyrazolines
ANTIMICROBIAL AGENTS
hybrids
THERMAL-DECOMPOSITION
HIGHLY EFFICIENT
triazole
ALCOHOLS
REUSABLE CATALYST
PHENOLS
ACETIC-ANHYDRIDE
DERIVATIVES
hydrazones
Acylation
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Summary:An efficient synthesis of N-acyl/N-substituted acyl pyrazolines and their triazole hybrids have been accomplished via acylation of pyrazolines and pyrazoline-triazole hybrids with carboxylic acids and/or substituted carboxylic acids in the absence of activating agents/catalysts. In the present study, a mechanism envisaging the in situ generation of a new transient acylating intermediate has been proposed to explain the acylation.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2015.1104357