From isocyanides to trichloropyruvamides: application to a new preparation of oxamide derivatives

[Display omitted] Isocyanides react readily with trichloroacetic acid anhydride forming stable hydrates of trichloropyruvamides. These compounds are valuable intermediates for obtaining oxamides by reaction with TMSCl/NEt 3 followed by addition of an amine.

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Bibliographic Details
Published inTetrahedron letters Vol. 45; no. 43; pp. 8047 - 8048
Main Authors El Kaim, Laurent, Gaultier, Laetitia, Grimaud, Laurence, Vieu, Emilie
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 18.10.2004
Elsevier
Subjects
Amide
Chemical Sciences
Chemistry
Chemistry, Organic
Isocyanides
Organic chemistry
Physical Sciences
Pyruvamide
Science & Technology
Trichloromethyl
Amide
Pyruvamide
Trichloromethyl
Isocyanides
TRIFLUOROACETIC-ANHYDRIDE
ACID-DERIVATIVES
isocyanides
amide
HALOFORM
TRIFLUOROPYRUVAMIDES
pyruvamide
ACCESS
trichloromethyl
trichloropyruvamides
oxamides
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Summary:[Display omitted] Isocyanides react readily with trichloroacetic acid anhydride forming stable hydrates of trichloropyruvamides. These compounds are valuable intermediates for obtaining oxamides by reaction with TMSCl/NEt 3 followed by addition of an amine.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.08.169