An efficient synthesis of thiazolo[3,2- a]pyrimidinones

A series of thiazolo[3,2- a]pyrimidinones was synthesised in a two-step procedure, using Eaton’s reagent to effect cyclisation of 2-aminothiazoles. The use of relatively low temperatures, facile product isolation and short reaction times make this cyclisation procedure a particularly attractive opti...

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Bibliographic Details
Published inTetrahedron letters Vol. 51; no. 25; pp. 3263 - 3265
Main Authors Ahmad, Nadia M., Jones, Keith
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 23.06.2010
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
4-QUINOLONES
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Summary:A series of thiazolo[3,2- a]pyrimidinones was synthesised in a two-step procedure, using Eaton’s reagent to effect cyclisation of 2-aminothiazoles. The use of relatively low temperatures, facile product isolation and short reaction times make this cyclisation procedure a particularly attractive option over more conventional methods.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.04.052