Naringenin as a Natural Agent Against Oxidative Stress and Inflammation, and Its Bioavailability

Naringenin is a flavanone commonly found in citrus and aromatic herbs that can protect against oxidative stress and inflammation. Oxidative stress can cause serious damage to tissues and organs; furthermore, it is closely related to chronic inflammation-related diseases, as reactive oxygen species c...

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Published inFood reviews international Vol. 39; no. 9; pp. 6707 - 6745
Main Authors Picos-Salas, Manuel Adrian, Cabanillas-Bojórquez, Luis Ángel, Elizalde-Romero, Cristina Alicia, Leyva-López, Nayely, Montoya-Inzunza, Luis Aurelio, Heredia, J. Basilio, Gutiérrez-Grijalva, Erick P.
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 03.10.2023
Taylor & Francis Ltd
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Abstract Naringenin is a flavanone commonly found in citrus and aromatic herbs that can protect against oxidative stress and inflammation. Oxidative stress can cause serious damage to tissues and organs; furthermore, it is closely related to chronic inflammation-related diseases, as reactive oxygen species can activate transcription factors that culminate in the production of pro-inflammatory molecules. The effects of naringenin against these responses are mediated by its antioxidant capacity and the induction or inhibition of signaling routes related to inflammation. Hence the current review summarizes the current knowledge of naringenin's health benefits against oxidative stress and inflammation, its mechanisms of action, and its bioavailability.
AbstractList Naringenin is a flavanone commonly found in citrus and aromatic herbs that can protect against oxidative stress and inflammation. Oxidative stress can cause serious damage to tissues and organs; furthermore, it is closely related to chronic inflammation-related diseases, as reactive oxygen species can activate transcription factors that culminate in the production of pro-inflammatory molecules. The effects of naringenin against these responses are mediated by its antioxidant capacity and the induction or inhibition of signaling routes related to inflammation. Hence the current review summarizes the current knowledge of naringenin's health benefits against oxidative stress and inflammation, its mechanisms of action, and its bioavailability.
Author Elizalde-Romero, Cristina Alicia
Gutiérrez-Grijalva, Erick P.
Heredia, J. Basilio
Leyva-López, Nayely
Picos-Salas, Manuel Adrian
Cabanillas-Bojórquez, Luis Ángel
Montoya-Inzunza, Luis Aurelio
Author_xml – sequence: 1
  givenname: Manuel Adrian
  orcidid: 0000-0001-8899-1029
  surname: Picos-Salas
  fullname: Picos-Salas, Manuel Adrian
  organization: Centro de Investigación en Alimentación y Desarrollo A.C
– sequence: 2
  givenname: Luis Ángel
  orcidid: 0000-0002-8943-2891
  surname: Cabanillas-Bojórquez
  fullname: Cabanillas-Bojórquez, Luis Ángel
  organization: Centro de Investigación en Alimentación y Desarrollo A.C
– sequence: 3
  givenname: Cristina Alicia
  orcidid: 0000-0002-2338-9894
  surname: Elizalde-Romero
  fullname: Elizalde-Romero, Cristina Alicia
  organization: Centro de Investigación en Alimentación y Desarrollo A.C
– sequence: 4
  givenname: Nayely
  orcidid: 0000-0001-6222-6169
  surname: Leyva-López
  fullname: Leyva-López, Nayely
  organization: Centro de Investigación en Alimentación y Desarrollo A.C
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  givenname: Luis Aurelio
  orcidid: 0000-0003-3327-1053
  surname: Montoya-Inzunza
  fullname: Montoya-Inzunza, Luis Aurelio
  organization: Centro de Investigación en Alimentación y Desarrollo A.C
– sequence: 6
  givenname: J. Basilio
  orcidid: 0000-0003-1017-957X
  surname: Heredia
  fullname: Heredia, J. Basilio
  organization: Centro de Investigación en Alimentación y Desarrollo A.C
– sequence: 7
  givenname: Erick P.
  orcidid: 0000-0002-1366-408X
  surname: Gutiérrez-Grijalva
  fullname: Gutiérrez-Grijalva, Erick P.
  email: erickpaulggrijalva@gmail.com
  organization: Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo A.C
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CitedBy_id crossref_primary_10_2174_1573409919666230612103201
crossref_primary_10_1038_s41598_023_50997_2
crossref_primary_10_3390_ijms24129856
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Snippet Naringenin is a flavanone commonly found in citrus and aromatic herbs that can protect against oxidative stress and inflammation. Oxidative stress can cause...
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SubjectTerms Bioavailability
extraction
Inflammation
MAPK
Naringenin
NF-κB
Nrf2, cytokines
Oxidative stress
Reactive oxygen species
Transcription factors
Title Naringenin as a Natural Agent Against Oxidative Stress and Inflammation, and Its Bioavailability
URI https://www.tandfonline.com/doi/abs/10.1080/87559129.2022.2123502
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