Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition

• Published in: Psychiatry investigation Vol. 20; no. 12; pp. 1177 - 1184
• Main Authors: Choi, In Hyeok, Wang, Sheng-Min, Um, Yoo Hyun, Lim, Hyun Kook, Lee, Chang Uk, Kang, Dong Woo
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Neuropsychiatric Association 01.12.2023; 대한신경정신의학회
• Subjects: Original; 정신과학; Functional neuroimaging; Apolipoprotein; Mild cognitive impairment; Body composition; Bioelectrical impedance
• ISSN: 1738-3684; 1976-3026
• DOI: 10.30773/pi.2023.0138

We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI) patients with Aβ deposition. MCI patients with and without APOE ε4 allele (carrier, n=86; non-carrier, n=95) underwent neuropsychological battery, resting-state functional magnetic resonance imaging scans, positron emission tomography scans with [18F]flutemetamol, and bioelectrical impedance analysis for measuring body composition. We employed a priori defined regions of interest to investigate the intra- and inter-network FC profiles of default mode network (DMN), central executive network (CEN), and salience network. There was a significant interaction of APOE ε4 carrier status with body fat mass index, visceral fat area, and waist-hip circumference ratio for inter-network FC between DMN and CEN, contributing higher fat-related body composition measurements in the APOE ε4 carrier with lower DMN-CEN FC. The present results highlight the detrimental effect of APOE ε4 carrier status on the associations between the fat-related body composition measurements and FC in the MCI patients with Aβ accumulation.