Dynamic resource allocation for controlling pathogen spread on a large metapopulation network
To control the spread of an infectious disease over a large network, the optimal allocation by a social planner of a limited resource is a fundamental and difficult problem. We address this problem for a livestock disease that propagates on an animal trade network according to an epidemiological-dem...
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Published in | Journal of the Royal Society interface Vol. 19; no. 188; p. 20210744 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
the Royal Society
01.03.2022
The Royal Society |
Subjects | |
Online Access | Get full text |
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Summary: | To control the spread of an infectious disease over a large network, the optimal allocation by a social planner of a limited resource is a fundamental and difficult problem. We address this problem for a livestock disease that propagates on an animal trade network according to an epidemiological-demographic model based on animal demographics and trade data. We assume that the resource is dynamically allocated following a certain score, up to the limit of resource availability. We adapt a greedy approach to the metapopulation framework, obtaining new scores that minimize approximations of two different objective functions, for two control measures: vaccination and treatment. Through intensive simulations, we compare the greedy scores with several heuristics. Although topology-based scores can limit the spread of the disease, information on herd health status seems crucial to eradicating the disease. In particular, greedy scores are among the most effective in reducing disease prevalence, even though they do not always perform the best. However, some scores may be preferred in real life because they are easier to calculate or because they use a smaller amount of resources. The developed approach could be adapted to other epidemiological models or to other control measures in the metapopulation setting. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 PMCID: PMC8905161 Electronic supplementary material is available online at https://doi.org/10.6084/m9.figshare.c.5872682. |
ISSN: | 1742-5662 1742-5689 1742-5662 |
DOI: | 10.1098/rsif.2021.0744 |