Experimental fat embolism: a dynamic assessment of pulmonary fat-handling characteristics

Injection 125I-glyceryl trioleate (0-5 mg/kg) into the right atrium of anaesthetized greyhounds caused the following changes: sequestration of far in the right side of the heart; 95 per cent removal by the lungs in a single passage through the pulmonary circulation; subsequent release of fat into th...

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Bibliographic Details
Published inBritish journal of surgery Vol. 64; no. 1; p. 11
Main Authors Sikorski, J M, Pardy, B J, Dudley, H A
Format Journal Article
LanguageEnglish
Published England 01.01.1977
Subjects
Animals
Dogs
Embolism, Fat - chemically induced
Embolism, Fat - metabolism
Fats, Unsaturated - blood
Lung - metabolism
Time Factors
Triolein - metabolism
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Summary:Injection 125I-glyceryl trioleate (0-5 mg/kg) into the right atrium of anaesthetized greyhounds caused the following changes: sequestration of far in the right side of the heart; 95 per cent removal by the lungs in a single passage through the pulmonary circulation; subsequent release of fat into the systemic circulation; rapid overall turnover of fat trapped in the lungs and slow removal of recirculating fat by other tissues. We believe that if there is release of unemulsified fat into the circulation in traumatic fat embolism these findings are of significance in interpreting the subsequent pulmonary events.
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.1800640104