Occurrence and Timing of Subsequent Severe Acute Respiratory Syndrome Coronavirus 2 Reverse-transcription Polymerase Chain Reaction Positivity Among Initially Negative Patients

Abstract Using data for 20 912 patients from 2 large academic health systems, we analyzed the frequency of severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction test discordance among individuals initially testing negative by nasopharyngeal swab who were ret...

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Published inClinical infectious diseases Vol. 72; no. 2; pp. 323 - 326
Main Authors Long, Dustin R, Gombar, Saurabh, Hogan, Catherine A, Greninger, Alexander L, O’Reilly-Shah, Vikas, Bryson-Cahn, Chloe, Stevens, Bryan, Rustagi, Arjun, Jerome, Keith R, Kong, Christina S, Zehnder, James, Shah, Nigam H, Weiss, Noel S, Pinsky, Benjamin A, Sunshine, Jacob E
Format Journal Article
LanguageEnglish
Published US Oxford University Press 27.01.2021
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Abstract Abstract Using data for 20 912 patients from 2 large academic health systems, we analyzed the frequency of severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction test discordance among individuals initially testing negative by nasopharyngeal swab who were retested on clinical grounds within 7 days. The frequency of subsequent positivity within this window was 3.5% and was similar across institutions.
AbstractList Abstract Using data for 20 912 patients from 2 large academic health systems, we analyzed the frequency of severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction test discordance among individuals initially testing negative by nasopharyngeal swab who were retested on clinical grounds within 7 days. The frequency of subsequent positivity within this window was 3.5% and was similar across institutions.
Using data for 20 912 patients from 2 large academic health systems, we analyzed the frequency of severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction test discordance among individuals initially testing negative by nasopharyngeal swab who were retested on clinical grounds within 7 days. The frequency of subsequent positivity within this window was 3.5% and was similar across institutions.Using data for 20 912 patients from 2 large academic health systems, we analyzed the frequency of severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction test discordance among individuals initially testing negative by nasopharyngeal swab who were retested on clinical grounds within 7 days. The frequency of subsequent positivity within this window was 3.5% and was similar across institutions.
Using data for 20 912 patients from 2 large academic health systems, we analyzed the frequency of severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction test discordance among individuals initially testing negative by nasopharyngeal swab who were retested on clinical grounds within 7 days. The frequency of subsequent positivity within this window was 3.5% and was similar across institutions.
Author Bryson-Cahn, Chloe
Kong, Christina S
Shah, Nigam H
Jerome, Keith R
Pinsky, Benjamin A
Hogan, Catherine A
Weiss, Noel S
Zehnder, James
Sunshine, Jacob E
Long, Dustin R
Greninger, Alexander L
O’Reilly-Shah, Vikas
Rustagi, Arjun
Gombar, Saurabh
Stevens, Bryan
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  givenname: Saurabh
  surname: Gombar
  fullname: Gombar, Saurabh
  organization: Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
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  givenname: Catherine A
  surname: Hogan
  fullname: Hogan, Catherine A
  organization: Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
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  surname: Greninger
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  organization: Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA
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  surname: O’Reilly-Shah
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  organization: Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, Washington, USA
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  organization: Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
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  surname: Rustagi
  fullname: Rustagi, Arjun
  organization: Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
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  surname: Jerome
  fullname: Jerome, Keith R
  organization: Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA
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  surname: Kong
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  organization: Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
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  surname: Shah
  fullname: Shah, Nigam H
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  surname: Weiss
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10.1056/NEJMoa2001191
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Keywords COVID-19
SARS-CoV-2
RT-PCR
nasopharyngeal
test characteristics
Language English
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Published by Oxford University Press for the Infectious Diseases Society of America 2020.
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University of Washington Laboratory Medicine (2021012703150957500_CIT0010)
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Snippet Abstract Using data for 20 912 patients from 2 large academic health systems, we analyzed the frequency of severe acute respiratory syndrome coronavirus 2...
Using data for 20 912 patients from 2 large academic health systems, we analyzed the frequency of severe acute respiratory syndrome coronavirus 2...
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SubjectTerms COVID-19
COVID-19 Testing
Humans
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2
Title Occurrence and Timing of Subsequent Severe Acute Respiratory Syndrome Coronavirus 2 Reverse-transcription Polymerase Chain Reaction Positivity Among Initially Negative Patients
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