Increased serum monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and interleukin-8 concentrations in hemophagocytic lymphohistiocytosis

• Published in: Pediatric Blood & Cancer Vol. 51; no. 5; pp. 662 - 668
• Main Authors: Tamura, Kazushi, Kanazawa, Takashi, Tsukada, Shota, Kobayashi, Tohru, Kawamura, Machiko, Morikawa, Akihiro
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2008
• Subjects: cytokine; hemophagocytic lymphohistiocytosis (HLH); interleukin (IL)-8; macrophage inflammatory protein-1β (MIP-1β); monocyte chemoattractant protein-1 (MCP-1)

Background Hemophagocytic lymphohistiocytosis (HLH) is characterized by hypercytokinemia caused by macrophage and T cell activation. We analyzed the serum concentrations of monocyte chemoattractant protein (MCP)‐1, macrophage inflammatory protein (MIP)‐1β, and interleukin (IL)‐8 to investigate the r...