Increased serum monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and interleukin-8 concentrations in hemophagocytic lymphohistiocytosis
Background Hemophagocytic lymphohistiocytosis (HLH) is characterized by hypercytokinemia caused by macrophage and T cell activation. We analyzed the serum concentrations of monocyte chemoattractant protein (MCP)‐1, macrophage inflammatory protein (MIP)‐1β, and interleukin (IL)‐8 to investigate the r...
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Published in | Pediatric Blood & Cancer Vol. 51; no. 5; pp. 662 - 668 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.11.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Background
Hemophagocytic lymphohistiocytosis (HLH) is characterized by hypercytokinemia caused by macrophage and T cell activation. We analyzed the serum concentrations of monocyte chemoattractant protein (MCP)‐1, macrophage inflammatory protein (MIP)‐1β, and interleukin (IL)‐8 to investigate the roles of these chemokines in the pathophysiology of HLH.
Methods
Seven patients clinically diagnosed with HLH were examined. Serum cytokines and chemokines were measured. The differences in the serum concentrations between the patients with HLH and the controls were investigated.
Results
In patients with an active phase of HLH, the serum MCP‐1, MIP‐1β, and IL‐8 levels all were significantly higher than in healthy controls. The chemokine elevations decreased rapidly after initiation of chemotherapy. During increases in disease activity, elevation of MCP‐1 and MIP‐1β preceded elevation of the serum ferritin level, which is a clinical indicator of HLH disease activity.
Conclusions
These results suggest that MCP‐1, MIP‐1β, and IL‐8 play important roles in the pathophysiology of HLH. In addition, the serum concentrations of these chemokines may be sensitive markers for assessing disease activity in patients with HLH. Pediatr Blood Cancer 2008;51:662–668. © 2008 Wiley‐Liss, Inc. |
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Bibliography: | Kawano Masanori Memorial Foundation for the Promotion of Pediatrics ArticleID:PBC21660 istex:9609F88D2437AD1F7FC99DA3CF420D1F0FC5A626 ark:/67375/WNG-Q0NR523Z-Q Ministry of Health, Labor and Welfare, Japan ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1545-5009 1545-5017 1096-911X |
DOI: | 10.1002/pbc.21660 |