Efficient solid-phase synthesis of perfluoroalkylated dimerizable cationic detergents for gene delivery

A new straightforward solid-phase synthesis of perfluoroalkylated dimerizable detergents used as gene delivery systems is presented. This route using Fmoc-Cys(SASRIN™ _®)-OH resin as solid support affords the target products in almost quantitative yields and high purity.

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Bibliographic Details
Published inTetrahedron letters Vol. 50; no. 5; pp. 562 - 563
Main Authors Guilloteau, Nicolas, Gourriérec, Loïc Le, Fabio, Karine, Giorgio, Christophe Di, Greiner, Jacques, Vierling, Pierre
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 04.02.2009
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
INTRACELLULAR DELIVERY
NANOMETRIC DNA PARTICLES
FORMULATION
ACIDS
PLASMID DNA
ARTIFICIAL VIRUSES
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Summary:A new straightforward solid-phase synthesis of perfluoroalkylated dimerizable detergents used as gene delivery systems is presented. This route using Fmoc-Cys(SASRIN™ _®)-OH resin as solid support affords the target products in almost quantitative yields and high purity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2008.11.072