The bi-metallic MOF-919 (Fe-Cu) nanozyme capable of bifunctional enzyme-mimicking catalytic activity

• Published in: Chemical communications (Cambridge, England) Vol. 58; no. 4; pp. 569 - 572
• Main Authors: Kulandaivel, Sivasankar, Lin, Chia-Her, Yeh, Yi-Chun
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 06.01.2022
• Subjects: Biocatalysis; Biosensing Techniques; Biosensors; Catalytic activity; Colorimetry; Copper; Copper - chemistry; Copper - metabolism; Enzymes; Epinephrine; Iron; Iron - chemistry; Iron - metabolism; Metal-organic frameworks; Metal-Organic Frameworks - chemistry; Metal-Organic Frameworks - metabolism; Molecular Structure; Nanosensors; Oxidase; Oxidoreductases - chemistry; Oxidoreductases - metabolism; Peroxidase; Peroxidase - chemistry; Peroxidase - metabolism; Phenylenediamine; Phenylenediamines - analysis; Phenylenediamines - metabolism; Substrates; Transition metals
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/d1cc05908d

In this study, we report on a bi-metal organic framework, MOF-919 (Fe-Cu), capable of bifunctional-enzyme mimicking activity with oxidase- and peroxidase-like activities. The catalytic activities were examined by using o -phenylenediamine (OPD) as a chromogenic substrate to study oxidase- and peroxidase-like mimetics. Based on our findings, we developed a simple epinephrine colorimetric biosensor with a broad linear range (1-100 μM) and a low detection limit (0.298 μM). This approach provides evidence for transition metal-based pristine bi-metallic MOFs capable of reproducing both oxidase-peroxidase properties, which could be applied as new nanosensors. In this study, we report on a bi-metal organic framework, MOF-919 (Fe-Cu), capable of bifunctional-enzyme mimicking activity with oxidase- and peroxidase-like activities.