Prognostic value of mean platelet volume in patients with non-ST-elevation acute coronary syndrome

• Published in: Angiology Vol. 63; no. 4; p. 241
• Main Authors: López-Cuenca, Angel A, Tello-Montoliu, Antonio, Roldán, Vanessa, Pérez-Berbel, Patricio, Valdés, Mariano, Marín, Francisco
• Format: Journal Article
• Language: English
• Published: United States 01.05.2012
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - diagnosis; Biomarkers; Blood Platelets - cytology; Cell Size; Female; Follow-Up Studies; Humans; Male; Prognosis; Regression Analysis
• ISSN: 1940-1574
• DOI: 10.1177/0003319711413892

The aim of this study is to determine mean platelet volume (MPV) in a population with non-ST-elevation acute coronary syndrome (nSTEACS) and explore its relation with prognosis. Patients (n = 329) with a diagnosis of nSTEACS at admission were recruited, with a determination of MPV in the first 12 hours at admission. We also collected blood from 87 healthy controls. A composite end point of cardiovascular death and new ACS was assessed at 6-month follow-up. Patients with nSTEACS showed larger platelets (MPV: 11.0 [10.3-11.8] vs 9.2 [8.6-10.0] fL; P < .001.). In Cox regression analysis, MPV at admission was a significant predictor of cardiovascular adverse events in univariate analysis, hazard ratio (HR) 1.4 95% confidence interval (CI) 1.1-1.8; P = .018; but after adjustment with clinical variables, MPV lost its statistical significance. In conclusion, patients with nSTEACS present with larger platelets than healthy controls, however this parameter did not show an independent prognostic significance at 6-month follow-up.