Fe in biosynthesis, translocation, and signal transduction of NO: toward bioinorganic engineering of dinitrosyl iron complexes into NO-delivery scaffolds for tissue engineering
Iron, the most abundant transition metal ion in humans, participates in the biosynthesis, translocation, signal transduction, and transformation of nitric oxide through its encapsulation in the form of heme, [Fe-S], and [Fe(NO) 2 ] cofactors within a variety of enzymes and proteins. After the review...
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| Published in | Dalton transactions : an international journal of inorganic chemistry Vol. 48; no. 26; pp. 9431 - 9453 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
02.07.2019
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Iron, the most abundant transition metal ion in humans, participates in the biosynthesis, translocation, signal transduction, and transformation of nitric oxide through its encapsulation in the form of heme, [Fe-S], and [Fe(NO)
2
] cofactors within a variety of enzymes and proteins. After the review on nitric oxide synthase (NOS) and soluble guanylate cyclase (sGC) for the biosynthesis and detection of NO, in this report, we discuss the natural utilization of the [Fe(NO)
2
] motif for translocation of endogenous NO and the translational development of synthetic dinitrosyl iron complexes (DNICs) for biomedical applications. A mechanistic study of NO-release and NO-transfer reactivity of structure-characterized DNICs promoted the discovery of cell-penetrating and
in vivo
NO-delivery reactivity for treatment of cancer and wound healing in diabetes. Beyond activation of sGC and vasodilation, phase I/II clinical trials of glutathione-bound DNICs (Oxacom®) against hypertension encourage bioinorganic engineering of DNICs into scaffolds for tissue regeneration and repair relying on anti-bacterial, anti-inflammation, cytoprotective, and proliferative effects of NO.
The ubiquitous physiology of nitric oxide enables the bioinorganic engineering of [Fe(NO)
2
]-containing and NO-delivery scaffolds for tissue engineering. |
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| Bibliography: | Hui-Yi Hsiao was born in Yunlin, Taiwan, in 1979. She received her B.S. degree in Biology from Tunghai University, Taiwan in 2001. Under the supervision of Prof. Claude Desplan, she received her Ph.D. degree in Developmental Biology from New York University, New York, USA with the honor of MacCracken Fellowship in 2013. Her PhD research focussed on the signaling transduction pathway involved in photoreceptor fate determination. In the same year, she joined the Center for Tissue Engineering, Chang Gung Memorial Hospital, as a post-doctoral fellow working on tissue engineering and tissue regeneration. Since 2017, she has been serving as an assistant research fellow in the same institute. Her current research interests include the regeneration of adipose, bone and cartilage tissue with the combination of novel biomaterials and adult stem cells. Oliver B. Villaflores is an Associate Professor at the University of Santo Tomas. He is currently handling chemistry courses in both the undergraduate and graduate programs of the university. He holds a Ph.D. degree in Chemistry from the Chung Yuan Christian University, Taiwan, where he was a recipient of the Distinguished International Graduate Student scholarship program. His research interests include discovery of potential natural products and peptides from Philippine plants and marine resources and studying their effects on angiogenesis, hypertension, diabetes and Alzheimer's disease. He is also involved in research studies on biocatalytic production of ethanol from waste cellulosic materials as renewable energy sources. Chieh-Wei Chung was born in Taichung, Taiwan, in 1996. He received his B.S. degree in Materials Science and Engineering from National Tsing Hua University in 2016. Under the supervision of Prof. Tsai-Te Lu, now, he is a graduate student in the Institute of Biomedical Engineering, National Tsing Hua University (Taiwan). Tsai-Te Lu was born in Hsinchu, Taiwan in 1983. He received his B.S. degree in Chemistry from National Tsing Hua University (2005). Under the supervision of Prof. Wen-Feng Liaw, he received his Ph.D. degree in Chemistry from National Tsing Hua University (2009) with the NTHU President's Scholarship and the Phi Tau Phi Scholastic Honor. After a 2-year postdoctoral research with Prof. Wen-Feng Liaw, he received Postdoctoral Research Abroad Program Fellowship (National Science Council) to continue the postdoctoral study with Prof. Stephen J. Lippard in the Department of Chemistry at MIT (2011-2013). He started his independent research career in the Department of Chemistry at Chung Yuan Christian University in 2013 before he joined the Institute of Biomedical Engineering in National Tsing Hua University in 2017. Joshua Santos was born in Manila, Philippines, in 1993. He received his B.S. and master's degrees in Pharmacy at the University of Santo Tomas in 2013 and 2015, respectively. Currently, he is a Ph.D. student majoring in Pharmacy at the University of Santo Tomas Graduate School under the mentorship of Dr Mary Jho-Anne Corpuz and Dr Oliver Villaflores. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1477-9226 1477-9234 |
| DOI: | 10.1039/c9dt00777f |