Intermolecular trifluoromethyl-alkenylation of alkenes enabled by metal-free photoredox catalysis

A three-component and redox-neutral trifluoromethylative alkenylation of unactivated alkenes with β-nitrostyrenes has been developed under visible-light. This metal-free protocol utilizes the easy to handle Langlois reagent (CF 3 SO 2 Na) as the CF 3 source and is suitable for various unactivated al...

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Published inChemical communications (Cambridge, England) Vol. 57; no. 45; pp. 5582 - 5585
Main Authors Kulthe, Arun D, Mainkar, Prathama S, Akondi, Srirama Murthy
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 03.06.2021
Royal Society of Chemistry
Subjects
Alkenes
Chemistry
Chemistry, Multidisciplinary
Photoredox catalysis
Physical Sciences
Reagents
Science & Technology
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Summary:A three-component and redox-neutral trifluoromethylative alkenylation of unactivated alkenes with β-nitrostyrenes has been developed under visible-light. This metal-free protocol utilizes the easy to handle Langlois reagent (CF 3 SO 2 Na) as the CF 3 source and is suitable for various unactivated alkenes and β-nitrostyrenes, affording a series of trifluoromethylated aromatic alkenes under mild conditions in good to excellent yields. A three component trifluoromethyl-alkenylation of alkenes under organic photoredox conditions is reported.
Bibliography:10.1039/d1cc01806j
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc01806j