Enantioselective catalytic Povarov reactions
Catalytic asymmetric Povarov protocols have undergone an explosive growth, especially in the last ten years, since the first example was published in 1996. The use of chiral Lewis and Brønsted acids and dual strategies based on their combination with catalysts acting by hydrogen bond formation, as w...
Saved in:
| Published in | Organic & biomolecular chemistry Vol. 2; no. 8; pp. 155 - 1581 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
23.02.2022
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Summary: | Catalytic asymmetric Povarov protocols have undergone an explosive growth, especially in the last ten years, since the first example was published in 1996. The use of chiral Lewis and Brønsted acids and dual strategies based on their combination with catalysts acting by hydrogen bond formation, as well as covalent aminocatalysis, are reviewed. More recent variations such as the nitroso Povarov reaction and interrupted Povarov reactions as a route to chiral scaffolds other than tetrahydroquinolines are also discussed.
Catalytic asymmetric Povarov reactions are reviewed, with emphasis on the use of chiral Lewis and Brønsted acids, H-bond forming catalysts and aminocatalysis. Enantioselective nitroso Povarov and interrupted Povarov reactions are also discussed. |
|---|---|
| Bibliography: | José Carlos Menéndez obtained a Ph. D. in Pharmacy from UCM and, after postdoctoral work with Prof. Steven Ley at Imperial College, he joined the UCM Organic and Medicinal Chemistry Department, where he is now a full professor. His interests include the development of multiple bond-forming reactions for library synthesis by environmentally benign methods. His medicinal chemistry projects aim at the discovery of new anticancer, antitubercular, leishmanicidal and neuroprotective compounds, usually applying in-house developed synthetic methodology. This work has been documented in about 300 primary articles, reviews and chapters and 15 patents. In 2017, he was elected as a member of the Spanish Royal Academy of Pharmacy. María Teresa Ramos obtained a BSc and a PhD in Pharmacy from UCM. She joined the group of Prof. G. A. Olah (USC, Los Angeles) for a postdoctoral stay, after which she became an Assistant Professor at the Organic and Medicinal Chemistry Department, UCM. Her research interests are focused on the development of new methodologies for the synthesis of heterocycles and their application in medicinal chemistry. José Clerigué studied Pharmacy at UCM and, after a traineeship at the Institut de Bactériologie of Strasbourg, he joined the Department of Organic and Medicinal Chemistry. His PhD Thesis, supervised by José Carlos Menéndez and María Teresa Ramos, is focused on new synthetic pathways starting from the aza-vinylogous Povarov reaction, with special interest in anti-neurodegenerative compounds. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 1477-0520 1477-0539 |
| DOI: | 10.1039/d1ob02270a |