Plasmonic silver and gold nanoparticles: shape- and structure-modulated plasmonic functionality for point-of-caring sensing, bio-imaging and medical therapy

Silver and gold nanoparticles have found extensive biomedical applications due to their strong localized surface plasmon resonance (LSPR) and intriguing plasmonic properties. This review article focuses on the correlation among particle geometry, plasmon properties and biomedical applications. It di...

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Published inChemical Society reviews Vol. 53; no. 6; pp. 2932 - 2971
Main Authors Hang, Yingjie, Wang, Anyang, Wu, Nianqiang
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 18.03.2024
Subjects
Biomedical materials
Controllability
Fluorescent indicators
Gold
In vivo methods and tests
Microfluidic devices
Nanoparticles
Nanorods
Nanospheres
Particle shape
Photoelectrochemistry
Plasmonics
Raman spectra
Silver
Surface plasmon resonance
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Summary:Silver and gold nanoparticles have found extensive biomedical applications due to their strong localized surface plasmon resonance (LSPR) and intriguing plasmonic properties. This review article focuses on the correlation among particle geometry, plasmon properties and biomedical applications. It discusses how particle shape and size are tailored via controllable synthetic approaches, and how plasmonic properties are tuned by particle shape and size, which are embodied by nanospheres, nanorods, nanocubes, nanocages, nanostars and coreshell composites. This article summarizes the design strategies for the use of silver and gold nanoparticles in plasmon-enhanced fluorescence, surface-enhanced Raman scattering (SERS), electroluminescence, and photoelectrochemistry. It especially discusses how to use plasmonic nanoparticles to construct optical probes including colorimetric, SERS and plasmonic fluorescence probes (labels/reporters). It also demonstrates the employment of Ag and Au nanoparticles in polymer- and paper-based microfluidic devices for point-of-care testing (POCT). In addition, this article highlights how to utilize plasmonic nanoparticles for in vitro and in vivo bio-imaging based on SERS, fluorescence, photoacoustic and dark-field models. Finally, this article shows perspectives in plasmon-enhanced photothermal and photodynamic therapy. Silver and gold nanoparticles have found extensive biomedical applications due to their strong localized surface plasmon resonance (LSPR) and intriguing plasmonic properties.
Bibliography:Yingjie Hang is currently a PhD candidate under the supervision of Prof. Nick Wu. in the Department of Chemical Engineering at University of Massachusettes Amherst, USA. She received her MS degree from Soochow University in 2019. Her research interests include plasmon-enhanced fluorescence and SERS for biosensors for point-of-care detection of protein and nucleic acids, as well as cellular sensors integrated with photodynamic therapy.
Dr Anyang Wang is a Postdoctoral Fellow under the supervision of Prof. Nick Wu in the Department of Chemical Engineering at University of Massachusettes Amherst, USA. He received his PhD degree from University at Buffalo, State University of New York in 2020, and MS and BS degrees from Tohoku University, Japan, in 2014 and 2012, respectively. His research interests include optical devices, especially plasmonic nanostructures for biosensing and light management technologies, as well as microfluidics for point-of-care testing.
Dr Nianqiang (Nick) Wu received his PhD degree in Materials Science & Engineering from Zhejiang University, China. Currently, he holds the position of Armstrong-Siadat Endowed Chair Professor in Materials Science at University of Massachusetts Amherst, USA. Dr Wu is a fellow of the Electrochemical Society (FECS), American Institute for Medical and Biological Engineering (F-AIMBE) and Royal Society of Chemistry (FRSC). He has received several honors and awards such as Highly Cited Researcher (Clarivate Analytics) and ECS Sensor Division Outstanding Achievement Award. He has authored or co-authored over 200 journal articles, 3 book chapters and 1 book entitled Biosensors Based on Nanomaterials and Nanodevices.
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ISSN:0306-0012
1460-4744
DOI:10.1039/d3cs00793f