Environmental factors affecting neural crest differentiation: Melanocyte differentiation by crest cells exposed to cell-free (deoxycholate-extracted) dermal mesenchyme matrix

Deoxycholate-extracted, cell-free matrices were prepared from primary explants or dispersed cell cultures of embryonic avian dermis, ectoderm, gut mesenchyme, endoderm, pharynx, or umbilical artery. Neural crest cells in association with matrices from dermal explants or monolayers formed melanocytes...

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Bibliographic Details
Published inCell and tissue research Vol. 225; no. 2; pp. 379 - 386
Main Author Derby, M.A
Format Journal Article
LanguageEnglish
Published Germany 01.01.1982
Subjects
animal anatomy
animal morphology
animal physiology
Animals
Cell Differentiation
Cells, Cultured
Central Nervous System - embryology
Chick Embryo
Coturnix
Deoxycholic Acid - pharmacology
Digestive System - embryology
Melanocytes - cytology
Mesoderm - physiology
Neural Crest - cytology
Pharynx - embryology
Skin - embryology
Umbilical Arteries - embryology
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Summary:Deoxycholate-extracted, cell-free matrices were prepared from primary explants or dispersed cell cultures of embryonic avian dermis, ectoderm, gut mesenchyme, endoderm, pharynx, or umbilical artery. Neural crest cells in association with matrices from dermal explants or monolayers formed melanocytes after six days. Crest cells in association with matrices from all other tissues or grown on plastic did not form melanocytes. It is concluded that a deoxycholate-resistant structural component of the dermal extracellular matrix induces melanocyte differentiation.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00214690