A highly sensitive fluorescent probe that quantifies transthyretin in human plasma as an early diagnostic tool of Alzheimer's disease

The development of sensitive and reliable fluorescent probes for the early diagnosis of Alzheimer's disease (AD) is highly challenging and plays an important role in achieving effective treatments. Herein, we designed and synthesized an indole-based fluorophore for TTR in human plasma, an impor...

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Published inChemical communications (Cambridge, England) Vol. 55; no. 7; pp. 1424 - 1427
Main Authors Lim, Hye Rim, Kim, Seo Yun, Jeon, Eun Hee, Kim, Yun Lan, Shin, Yu Mi, Koo, Tae-Sung, Park, Sung Jean, Hong, Ki Bum, Choi, Sungwook
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 27.08.2019
Royal Society of Chemistry
Subjects
Alzheimer Disease - blood
Alzheimer Disease - diagnosis
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Blood plasma
Chemistry
Chemistry, Multidisciplinary
Diagnostic software
Diagnostic systems
Fluorescent Dyes - chemistry
Fluorescent indicators
Humans
Limit of Detection
Pathogenesis
Physical Sciences
Prealbumin - metabolism
Science & Technology
Spectrometry, Fluorescence
CELLS
DYE
PROTEIN
AMYLOIDOGENESIS
ENZYMES
BRAIN
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Summary:The development of sensitive and reliable fluorescent probes for the early diagnosis of Alzheimer's disease (AD) is highly challenging and plays an important role in achieving effective treatments. Herein, we designed and synthesized an indole-based fluorophore for TTR in human plasma, an important hallmark of AD pathogenesis. This robust and simple fluorescent method allows quantification of TTR in the complex biological matrix. A robust and simple fluorescent assay for the quantification of TTR in human plasma was developed by utilizing an indole-based fluorophore.
Bibliography:Electronic supplementary information (ESI) available: General synthetic procedures, spectral data and other supplementary information. See DOI
10.1039/c9cc04172a
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc04172a