The first step of arsenoplatin-1 aggregation in solution unveiled by solving the crystal structure of its protein adduct

Arsenoplatin-1 (AP-1) is an innovative dual-action anticancer agent that contains a platinum( ii ) center coordinated to an arsenous acid moiety. We found that AP-1 spontaneously aggregates in aqueous solutions generating oligomeric species of increasing length. Afterward, we succeeded in solving th...

Full description

Saved in:
Bibliographic Details
Published inDalton transactions : an international journal of inorganic chemistry Vol. 5; no. 1; pp. 68 - 71
Main Authors Ferraro, Giarita, Cirri, Damiano, Marzo, Tiziano, Pratesi, Alessandro, Messori, Luigi, Merlino, Antonello
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 07.01.2021
Subjects
Agglomeration
Anticancer properties
Aqueous solutions
Crystal structure
Lysozyme
Platinum
Proteins
Trimers
Online AccessGet full text

Cover

More Information
Summary:Arsenoplatin-1 (AP-1) is an innovative dual-action anticancer agent that contains a platinum( ii ) center coordinated to an arsenous acid moiety. We found that AP-1 spontaneously aggregates in aqueous solutions generating oligomeric species of increasing length. Afterward, we succeeded in solving the crystal structure of the adduct formed between the model protein lysozyme and an early AP-1 oligomer that turned out to be a trimer. Remarkably, this crystal structure traps an early stage of AP-1 aggregation offering detailed insight into the molecular process of the oligomer's growth. AP-1 spontaneously aggregates in aqueous solutions. The structure of the adduct formed by an AP-1 trimer with lysozyme offers insight into the process of the oligomer's growth.
Bibliography:10.1039/D0DT04068A
Electronic supplementary information (ESI) available: DETAILS. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-9226
1477-9234
DOI:10.1039/d0dt04068a