Excited-state intramolecular proton transfer (ESIPT)-based fluorescent probes for biomarker detection: design, mechanism, and application
Biomarkers are essential in biology, physiology, and pharmacology; thus, their detection is of extensive importance. Fluorescent probes provide effective tools for detecting biomarkers exactly. Excited state intramolecular proton transfer (ESIPT), one of the significant photophysical processes that...
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| Published in | Chemical communications (Cambridge, England) Vol. 59; no. 15; pp. 256 - 271 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
16.02.2023
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Biomarkers are essential in biology, physiology, and pharmacology; thus, their detection is of extensive importance. Fluorescent probes provide effective tools for detecting biomarkers exactly. Excited state intramolecular proton transfer (ESIPT), one of the significant photophysical processes that possesses specific photoisomerization between Keto and Enol forms, can effectively avoid annoying interference from the background with a large Stokes shift. Hence, ESIPT is an excellent choice for biomarker monitoring. Based on the ESIPT process, abundant probes were designed and synthesized using three major design methods. In this review, we conclude probes for 14 kinds of biomarkers based on ESIPT explored in the past five years, summarize these general design methods, and highlight their application for biomarker detection
in vitro
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in vivo
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Biomarkers are essential in biology, physiology, and pharmacology; thus, their detection is of extensive importance. |
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| Bibliography: | Wenyan Wu graduated from Huainan Normal University (China) with BS degree in 2020 and is a master's student under the guidance of Prof. Chen, College of Chemical Engineering at Nanjing Tech University (China). She has been mainly involved in the research of polymer self-assembly and chiral induction for chiral and achiral molecules. Yongrong Liu graduated from Yancheng Normal University (China) with BS degree in 2020 and is a master's student under the guidance of Prof. Chen, College of Chemical Engineering at Nanjing Tech University (China). She has been mainly involved in the research of fluorescent chemosensors and chemiluminescent molecular probes. Fan Wang graduated from Anhui Science and Technology University (China) with his BS degree in 2019 and is a master's student under the guidance of Prof. Chen's group. He has been mainly involved in the research of developing chemiluminescent sensors. Hao Gu graduated from Shenyang University of Chemical Technology (China) with BS degree in 2017. He is pursuing his doctorate degree under the guidance of Prof. Chen's group, College of Chemical Engineering at Nanjing Tech University (China). He has been mainly involved in the research of fluorescent dyes, fluorescent chemosensors and photochromic dyes. Wenjing Wang graduated from Taizhou University (China) with BS degree in 2020 and is a master's student under the guidance of Prof. Chen, College of Chemical Engineering at Nanjing Tech University (China). She has been mainly involved in the research of fluorescent chemosensors and photochromic dyes. Yanjun Jiao graduated from Henan University of Science and Technology (China) with BS degree in 2020 and is a master's student under the guidance of Prof. Chen, College of Chemical Engineering at Nanjing Tech University (China). He has been mainly involved in the research of fluorescent dyes, fluorescent chemosensors and defaming agent. Fang Wang received her PhD from Ewha Womans University under the direction of Prof. Yoon (Korea) in 2012. She is currently a professor at Nanjing Tech University (China) and has joined Prof. Chen's group. Her research focuses on the design and synthesis of fluorescent chemosensors. Maolin Wang graduated from Xi'an University of Science and Technology (China) with BS degree in 2020 and is a master's student under the guidance of Prof. Chen, College of Chemical Engineering at Nanjing Tech University (China). She has been mainly involved in the research of fluorescent dyes, fluorescent chemosensors and photo-controlled release of active substance. Xiaoqiang Chen received his PhD in Applied Chemistry from Dalian University of Technology (China) in 2007. He joined Prof. Yoon's group at Ewha Womans University (Korea) as a postdoctoral fellow in 2008. In March 2010, he moved to Nanjing Tech University, where he is currently a professor of College of Chemical Engineering. He visited Ewha Womans University as a visiting professor in 2015. His current research interests mainly focus on fluorescent dyes, fluorescent probes, and light-controlled release of active substance. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/d2cc06556h |