Prostatic acid phosphatase, beta-glucuronidase and prostate specific antigen assays in fine needle aspirates from benign and malignant prostates

Enzymatic assays for tartrate-sensitive acid phosphatase and beta-glucuronidase, and radio-immunoassay for prostate-specific antigen, were modified for application to fine-needle aspirate samples from benign and malignant human prostates. When compared to samples from benign prostates, the ratio of...

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Bibliographic Details
Published inThe Journal of urology Vol. 146; no. 5; p. 1402
Main Authors Erickson, D R, Hlavinka, T C, Rockwood, A P, Metter, J D, Novicki, D E, Fried, M G
Format Journal Article
LanguageEnglish
Published United States 01.11.1991
Subjects
Acid Phosphatase - analysis
Antigens, Neoplasm - analysis
Biomarkers, Tumor - chemistry
Biopsy, Needle
Clinical Enzyme Tests - methods
Glucuronidase - analysis
Humans
Male
Prostate - enzymology
Prostate - immunology
Prostate - pathology
Prostate-Specific Antigen
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - pathology
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Summary:Enzymatic assays for tartrate-sensitive acid phosphatase and beta-glucuronidase, and radio-immunoassay for prostate-specific antigen, were modified for application to fine-needle aspirate samples from benign and malignant human prostates. When compared to samples from benign prostates, the ratio of acid phosphatase to beta-glucuronidase activities was significantly decreased in needle aspirates from malignant prostates. Prostate-specific antigen values in the aspirates did not correlate with malignancy.
ISSN:0022-5347
DOI:10.1016/S0022-5347(17)38124-7