Therapeutic efficacy of Phyllanthus emblica- coated iron oxide nanoparticles in A549 lung cancer cell line

Present work was undertaken to fabricate iron oxide nanoparticles (IONPs) using a green approach for increased therapeutic efficacy. Two types of IONPs were synthesized, one without any coating (IONP ) and other coated with (Amla) fruit extract (IONP ). Both the IONPs were characterized using differ...

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Published inNanomedicine (London, England) Vol. 14; no. 17; pp. 2355 - 2371
Main Authors Thoidingjam, Shivani, Tiku, Ashu Bhan
Format Journal Article
LanguageEnglish
Published England 01.09.2019
Subjects
amla extract
lung cancer
iron oxide
nanotherapy
reactive oxygen species
nanoparticle
phytochemical screening
green synthesis
iron oxide nanoparticle
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Summary:Present work was undertaken to fabricate iron oxide nanoparticles (IONPs) using a green approach for increased therapeutic efficacy. Two types of IONPs were synthesized, one without any coating (IONP ) and other coated with (Amla) fruit extract (IONP ). Both the IONPs were characterized using different techniques and therapeutic efficacy was evaluated in A549 human lung cancer cell line. IONP were smaller in size with better dispersibility compared with IONP . They induced increased reactive oxygen species production, higher DNA damage and apoptosis, which resulted in increased toxicity to cancer cells in comparison to IONP . Higher uptake of IONP and active components coating the surface, may be responsible for the increased therapeutic efficacy in cancer cells.
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ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2019-0111