Memory CD4+T cell profile is associated with unfavorable prognosis in IgG4-related disease: Risk stratification by machine-learning

• Published in: Clinical immunology (Orlando, Fla.) Vol. 252; p. 109301
• Main Authors: Nie, Yuxue, Liu, Zheng, Cao, Wei, Peng, Yu, Lu, Hui, Sun, Ruijie, Li, Jingna, Peng, Linyi, Zhou, Jiaxin, Fei, Yunyun, Li, Mengtao, Zeng, Xiaofeng, Zhang, Wen, Li, Taisheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2023
• Subjects: CD4-Positive T-Lymphocytes; Humans; IgG4-related disease; Immunoglobulin G4-Related Disease; Immunophenotype; Machine Learning; Prognosis; Risk Assessment; SHAP; Immunophenotype; IM; ROC; Th2 cells; AUC; IgG4-related disease; RTX; Tfh; RI; PD1; GC; TEM; IgG4-RD; ML; PLSDA

IgG4-related disease (IgG4-RD) is a chronic immune-mediated disease with heterogeneity. In this study, we used machine-learning approaches to characterize the immune cell profiles and to identify the heterogeneity of IgG4-RD. The XGBoost model discriminated IgG4-RD from HCs with an area under the re...