Facile multifunctional-mode of fabricated biocompatible human serum albumin/reduced graphene oxide/Cladophora glomerata nanoparticles for bacteriostatic phototherapy, bacterial tracking and antioxidant potential
To overcome multi-drug resistance in microbes, highly efficient antimicrobial substances are required that have a controllable antibacterial effect and are biocompatible. In the present study, an efficient phototherapeutic antibacterial agent, human serum albumin (HSA)/reduced graphene oxide (rGO)/...
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Published in | Nanotechnology Vol. 32; no. 31; pp. 315301 - 315318 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
IOP Publishing
30.07.2021
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Subjects | |
Online Access | Get full text |
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Summary: | To overcome multi-drug resistance in microbes, highly efficient antimicrobial substances are required that have a controllable antibacterial effect and are biocompatible. In the present study, an efficient phototherapeutic antibacterial agent, human serum albumin (HSA)/reduced graphene oxide (rGO)/
bionanocomposite was synthesized by the incorporation of rGO nanoparticles with HSA, forming protein-rGO, and decorated with a natural freshwater seaweed
. The prepared HSA/rGO/
bionanocomposite was characterized by spectroscopic (UV-vis, FTIR, XRD and Raman) and microscopic (TEM and SEM) techniques. The as-synthesized bionanocomposite showed that sunlight/NIR irradiation stimulated ROS-generating dual-phototherapic effects against antibiotic-resistant bacteria. The bionanocomposite exerted strong antibacterial effects (above 96 %) against amoxicillin-resistant
and
, in contrast to single-model-phototherapy. The bionanocomposite not only generated abundant ROS for killing bacteria, but also expressed a fluorescence image for bacterial tracking under sunlight/NIR irradiation. Additionally, the bionanocomposite displayed pronounced antioxidant activity. |
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Bibliography: | NANO-128140.R1 |
ISSN: | 0957-4484 1361-6528 |
DOI: | 10.1088/1361-6528/abf457 |