Luminescent switch sensors for the detection of biomolecules based on metal-organic frameworks

Metal-organic frameworks (MOFs) as sensing materials have experienced explosive growth in recent years due to their intrinsic merits, such as structural diversity, high porosity, large surface area, extraordinary adsorption affinities, etc . Biomolecules such as DNA, protein, and vitamins play vital...

Full description

Saved in:
Bibliographic Details
Published inAnalyst (London) Vol. 143; no. 18; pp. 4221 - 4229
Main Authors Zhang, Qi, Wang, Chen-Feng, Lv, Yun-Kai
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 10.09.2018
Subjects
Adsorption
Biomolecules
Deoxyribonucleic acid
DNA
DNA - analysis
Luminescent Agents - chemistry
Luminescent Measurements
Metabolism
Metal-organic frameworks
Metal-Organic Frameworks - chemistry
Porosity
Proteins
Proteins - analysis
Ribonucleic acid
RNA
RNA - analysis
Sensors
Vitamins
Online AccessGet full text

Cover

More Information
Summary:Metal-organic frameworks (MOFs) as sensing materials have experienced explosive growth in recent years due to their intrinsic merits, such as structural diversity, high porosity, large surface area, extraordinary adsorption affinities, etc . Biomolecules such as DNA, protein, and vitamins play vital roles in metabolism. Moreover, the sensitive detection of biomolecules is of importance in the disease prevention and treatment. This review intends to provide an update on the recent progress in the detection of various biomolecules via MOF-based luminescent sensors. MOFs are successful in the detection of DNA, RNA, protein, and other biomolecules. MOF-based luminescent sensors function by utilizing different mechanisms, including luminescent responses of enhancement and quenching, which are defined as "turn-on" and "turn-off" responses, respectively. Then, a short comparison of the "turn-on" and "turn-off" types of sensors is also made. The applications of MOFs-based luminescent sensors for biomolecules sensing via a "turn on" or "turn off" response have been reviewed.
Bibliography:Qi Zhang is a graduate student at the School of Science at Tianjin University. She received her bachelor's degree in chemistry from Hebei University. Now her research interests are the design and synthesis of luminescent metal-organic frameworks, and their applications in biomolecule sensing and the optical property adjustment in metal organic frameworks.
Prof. Yun-Kai Lv received his PhD from Nankai University, Tianjin in 2004. He is currently professor at the College of Chemistry and Environmental Sciences, Hebei University. His research areas include the synthesis of novel materials and their applications in separation and analysis, biosensor and catalytic degradation; application of biosensors (electrochemical sensing and fluorescence sensing) in biomolecules and disease markers; application of chromatography-mass spectrometry in the detection of pesticide veterinary drug residues, disease markers and air pollutants. He has published ∼80 peer-reviewed journal manuscripts and issued 4 Chinese invention patents.
Chenfeng Wang is a PhD graduate student majoring in analytical chemistry from the College of Chemistry and Environmental Sciences, Hebei University. Her current research program focuses on bioanalytical chemistry, in particular molecule fluorescence spectroscopy, electrochemical and biomolecular sensors, biomarkers and biological imaging.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0003-2654
1364-5528
DOI:10.1039/c8an00816g