Synthesis of NO-NSAID dendritic prodrugs via Passerini reaction: new approach to the design of dendrimer-drug conjugates

We report the synthesis of a novel class of dendritic prodrugs via Passerini reaction in one pot. Such dendrimers feature a simultaneous attachment of a conventional non-steroidal anti-inflammatory drug (NSAID) (such as ibuprofen and aspirin) and a nitric oxide (NO)-releasing moiety (such as an orga...

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Bibliographic Details
Published inJournal of chemical research Vol. 37; no. 3; pp. 181 - 185
Main Authors Du, Zuyin, Lu, Yanhui, Dai, Xuedong, Zhang-Negrerie, Daisy, Gao, Qingzhi
Format Journal Article
LanguageEnglish
Published LONDON Sage 01.03.2013
Sage Publications Ltd
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
dendrimers
NO-releasing NSAIDs
NONSTEROIDAL ANTIINFLAMMATORY DRUGS
dendritic prodrugs
RELAXING FACTOR
NITRIC-OXIDE
non-steroidal anti-inflammatory drugs
Passerini reaction
DELIVERY
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Summary:We report the synthesis of a novel class of dendritic prodrugs via Passerini reaction in one pot. Such dendrimers feature a simultaneous attachment of a conventional non-steroidal anti-inflammatory drug (NSAID) (such as ibuprofen and aspirin) and a nitric oxide (NO)-releasing moiety (such as an organic nitrate) onto their surface, and are therefore regarded as new drug delivery systems for NO-releasing NSAIDs (NO-NSAIDs).
ISSN:1747-5198
2047-6507
DOI:10.3184/174751913X13602469418189