Designing Medical Devices Based on Silicon Polymeric Material with Controlled Release of Local Anesthetics

• Published in: Journal of macromolecular science. Part A, Pure and applied chemistry Vol. 49; no. 5; pp. 439 - 444
• Main Authors: Petrisor, G., Ion, R. M., Brachais, C. H., Couvercelle, J-P., Chambin, O.
• Format: Journal Article
• Language: English
• Published: Colchester Taylor & Francis Group 01.05.2012; Taylor & Francis
• Subjects: Applied sciences; Biological and medical sciences; controlled release; cross-linking; drug delivery system; Exact sciences and technology; General pharmacology; Inorganic and organomineral polymers; lidocaine hydrochloride; Medical sciences; patch; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Properties and characterization; PVA; PVP; Silicone; water-soluble polymer; Dimethylsiloxane polymer; Control release polymer; Silicone; water-soluble polymer; Drug carrier; Semiinterpenetrating polymer network; PVP; lidocaine hydrochloride; Experimental study; Percutaneous route; Local anesthetic; Polyvinylalcohol; patch; controlled release; Pyrrolidone(vinyl) polymer; cross-linking; PVA; Kinetics; drug delivery system; Lidocaine; Cellulose ether; Cellulose(hydroxyethyl); Release; Silicone elastomer
• ISSN: 1060-1325; 1520-5738
• DOI: 10.1080/10601325.2012.672055

The drug delivery systems that are the object of this article take the form of a polymer matrix made of silicone containing a drug. These devices can be used as patches for local dermal applications releasing the drug in a controlled manner. The model active agent, lidocaine hydrochloride was chosen from the range of local anesthetics. When the drug is restricted to the surface, it is released more rapidly than when it is allowed to spread evenly throughout the silicon structure. When hydrophilic polymers such as PVA and HEC are mixed in with the lidocaine hydrochloride and deposited on the surface of the polymer matrix, we observed that the burst effect was eliminated without modifying the overall quantity of lidocaine hydrochloride released.