Interleukin-10 involvement in exposure to low dose of benzene

• Published in: Toxicology and industrial health Vol. 31; no. 4; pp. 351 - 354
• Main Authors: Spatari, Giovanna, Saitta, Salvatore, Giorgianni, Concetto, Cristani, Maria Teresa, Quattrocchi, Paolina, Abbate, Adriana, Carrieri, Mariella, Ferraro, Giorgia, Saija, Antonella, Gangemi, Sebastiano
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2015
• Subjects: Adult; Age Factors; Benzene - poisoning; Dose-Response Relationship, Drug; Extraction and Processing Industry - statistics & numerical data; Humans; Immune System - drug effects; Interleukin-10 - blood; Male; Middle Aged; Occupational Exposure - analysis; Occupational Exposure - statistics & numerical data; Petroleum; Sicily; Sicily; cytokines; regulatory T-cells; interleukin-10; Benzene
• ISSN: 0748-2337; 1477-0393; 1477-0393
• DOI: 10.1177/0748233713475518

Objective: To establish if serum levels of interleukin-10 (IL-10) in subjects exposed to benzene are connected with age, working years, and employment age. Methods: We evaluated serum levels of IL-10 in 51 employees working in oil refinery (group A) and in 16 office workers who resided in the same area (group B). Results: There was no statistically significant difference between serum concentrations of IL-10 in groups A and B. There was a statistically significant dependent relationship in group A between age, working years, and serum concentration of IL-10. There was a statistically significant and positive dependent relationship in group A between serum concentration of IL-10 and employment age. Conclusions: The role played by IL-10 in benzene immune suppression may be relevant and attention should be directed toward assessment of age, working years, and employment age in benzene-exposed populations.