Phase transfer of fatty acids into ultrasmall nanospheres for colorimetric detection of lipase and albumin

Colorimetric detection of fatty acids during biological interactions is extremely difficult since they are optically silent. Here, fatty acids are found to function as ion-exchangers in ultrasmall polymeric nanospheres to facilitate the protonation of chromoionophores, causing a vivid color change b...

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Published inChemical communications (Cambridge, England) Vol. 58; no. 32; pp. 537 - 54
Main Authors Guo, Chao, Zhai, Jingying, Chen, Qinghan, Du, Xinfeng, Xie, Xiaojiang
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 19.04.2022
Subjects
Albumins
Colorimetry
Fatty Acids
Ion exchangers
Lipase
Nanospheres
Oleic acid
Protonation
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Summary:Colorimetric detection of fatty acids during biological interactions is extremely difficult since they are optically silent. Here, fatty acids are found to function as ion-exchangers in ultrasmall polymeric nanospheres to facilitate the protonation of chromoionophores, causing a vivid color change between red and blue. With an excellent detection limit of 1.8 μg mL −1 for oleic acid, colorimetric assays for lipase and albumin are developed with quick response, high sensitivity, and low cost. This work reports the colorimetric real-time monitoring of the reaction and transfer of fatty acids from natural triglycerides.
Bibliography:10.1039/d2cc01089e
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc01089e