Selectfluor®-enabled photochemical selective C(sp)-H(sulfonyl)amidation

Transition metal- and photosensitizer-free C(sp 3 )-H (sulfonyl)amidation reactions have been realized by employing Selectfluor® as a versatile reagent, functioning as a photoactive component, a HAT precursor and an oxidant. Various toluene derivatives, cycloalkanes, natural products and bioactive m...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 1; pp. 118 - 121
Main Authors Chen, Yuehua, Yang, Boxuan, Li, Qian-Yu, Lin, Yu-Mei, Gong, Lei
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 22.12.2022
Royal Society of Chemistry
Subjects
Catalysis
Chemistry
Chemistry, Multidisciplinary
Diazonium Compounds
Molecular Structure
Natural products
Oxidizing agents
Physical Sciences
Reagents
Science & Technology
Selectivity
Toluene
Transition metals
FUNCTIONALIZATION
AMIDATION
AMINATION
HYDROCARBONS
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Summary:Transition metal- and photosensitizer-free C(sp 3 )-H (sulfonyl)amidation reactions have been realized by employing Selectfluor® as a versatile reagent, functioning as a photoactive component, a HAT precursor and an oxidant. Various toluene derivatives, cycloalkanes, natural products and bioactive molecules can be converted into N -containing products under mild conditions in good yield and with high chemo- and site-selectivity. Chemo- and site-selective C(sp 3 )-H sulfonylamidation and amidation of toluene derivatives, cycloalkanes, natural products and bioactive molecules has been achieved by employing Selectfluor® as a versatile reagent.
Bibliography:https://doi.org/10.1039/d2cc05569d
Electronic supplementary information (ESI) available. See DOI
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d2cc05569d