Recent synthetic methodologies for imidazo[1,5-]pyridines and related heterocycles
Imidazo[1,5- a ]pyridine is a significant structural component of a large number of agrochemicals and pharmaceuticals. The synthesis of imidazo[1,5- a ]pyridine has been a subject of intense research for numerous decades. A large number of transformations are now available to conveniently access imi...
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| Published in | Organic & biomolecular chemistry Vol. 2; no. 17; pp. 344 - 3468 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
04.05.2022
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Imidazo[1,5-
a
]pyridine is a significant structural component of a large number of agrochemicals and pharmaceuticals. The synthesis of imidazo[1,5-
a
]pyridine has been a subject of intense research for numerous decades. A large number of transformations are now available to conveniently access imidazo[1,5-
a
]pyridine from readily available starting materials. This review details the recent development in imidazo[1,5-
a
]pyridine construction involving cyclocondensation, cycloaddition, oxidative cyclization, and transannulation reactions.
This review summarizes the recent developments in the construction of imidazo[1,5-
a
]pyridines using cyclocondensation, cycloaddition, oxidative cyclization, and transannulation reactions. |
|---|---|
| Bibliography: | aerobic oxidative C-H activation. Dr Chanda began his postdoctoral studies first in peptoid catalysis with Prof. Galia Maayan at the Israel Institute of Technology, Technion, Israel. Later at Krembil Research Institut (Canada) in Prof. Donald Weaver's group, working on drug discovery in neuroinflammatory diseases. Since form 2021, he is working as a scientist at Paraza pharma, Canada. His current research focuses on the design and synthesis of small molecules for CNS diseases. Dr Harshita Kumari was born in Bareilly, India in 1982. She obtained her B.S. in Cosmetic Science from Nagpur University in 2005 and Ph.D. in Supramolecular Chemistry in 2011 under the supervision of Prof. Jerry L. Atwood. From 2009-2011, she was a foreign guest researcher at NIST Center for Neutron Research at National Research of Standards and Technology (NCNR-NIST). Her postdoctoral work (2011-2014) with Prof. Carol A. Deakyne was focused on computation chemistry of macrocycles and host-guest complexes. In 2015, she was appointed as Assistant Professor at University of Cincinnati and was promoted to Associate Professor in 2020. She has won several awards (Royal Society of Chemistry - Journals Grant for International Authors, Yardley Scholarly Excellence, Gold Medalist in Cosmetic Science), has published >65 journal articles, 5 book chapters and several patents. Her research interests include supramolecular chemistry, macrocyclic chemistry, crystal engineering, complex fluids and neutron scattering. Specifically, synthesis and characterization of novel nanometric delivery vehicles, based on the principles of self - assembly and molecular recognition. Her work focuses on integrating principles of modern biophysics into supramolecular complexes that would define the next generation of materials. Dr Rajendra D. Patil is Assistant Professor of Chemistry at the KCES's, Moolji Jaitha College, Jalgaon (Autonomous). He conducted postdoctoral research at the Nanyang Technological University, Singapore and The Hebrew University of Jerusalem, Israel. He received the B.Sc. Degree in Chemistry in 2004 and the M.Sc. degree in Organic Chemistry in 2006 from KBC-North Maharashtra University, Jalgaon, Maharashtra (India) and the Ph.D. Degree in Chemistry in 2012 from CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, India. His research and teaching interests include green chemistry, nano-catalysis and synthesis of biologically active molecules. He has published around 30 research papers in peer reviewed journals and national/international conferences. Dr Chandra Mohan Darapaneni received his PhD degree in 2016 from CSIR-Central Salt and Marine Chemicals Research Institute (India), under the supervision of Prof. S. Adimurthy for his work on the synthesis of bioactive fused nitrogen heterocyclic compounds Dr Ramana Reddy Mittapalli is currently working as Postdoctoral Research Fellow at University of Cincinnati, Dr Kumari Research Group, Cincinnati, Ohio, USA. He was a former Marie-Curie Postdoctoral researcher at University of Greenwich, Prof. Adrian P. Dobbs group, UK. He received the B.Sc. Degree in Chemistry in 2005, M.Sc. degree in Organic Chemistry in 2007 from S. V. University, Andhra Pradesh (India) and the Ph.D. Degree in Chemistry in 2015 from CSIR-IICT, Hyderabad, India. His research interests include Organic Synthesis, Medicinal Chemistry, green chemistry, Supramolecular Chemistry, Surfactant Chemistry and synthesis of biologically active natural products. He has published around 29 research papers in peer reviewed journals and national/international conferences. via ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 1477-0520 1477-0539 |
| DOI: | 10.1039/d2ob00386d |