Silver-catalyzed monofluoroalkylation of heteroarenes with α-fluorocarboxylic acids: an insight into the solvent effect

A mild and efficient method for direct C-H monofluoroalkylation of heteroarenes with easily accessible and inexpensive α-fluorocarboxylic acids has been developed. This silver-catalyzed reaction affords mono- and bis-monofluoroalkylated heteroarenes in good yields under mild conditions, and the solv...

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Published inChemical communications (Cambridge, England) Vol. 58; no. 8; pp. 1147 - 115
Main Authors Guo, Chunfang, Liu, Zhaolong, Li, Xiangye, Han, Xuliang, Li, Yueyun, Liu, Hui, Zhang, Lizhi, Li, Xinjin, Dong, Yunhui
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 25.01.2022
Subjects
Solvent effect
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Summary:A mild and efficient method for direct C-H monofluoroalkylation of heteroarenes with easily accessible and inexpensive α-fluorocarboxylic acids has been developed. This silver-catalyzed reaction affords mono- and bis-monofluoroalkylated heteroarenes in good yields under mild conditions, and the solvent effect on the monofluoroalkylation reaction is discussed in detail. Monofluoroalkylation: a mild and efficient method for the synthesis of mono- and bis-monofluoroalkylated heteroaromatic compounds was disclosed.
Bibliography:10.1039/d1cc06466e
Electronic supplementary information (ESI) available: Detailed experimental procedures and spectroscopic data. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc06466e