Differential Diagnosis Under the Microscope: Crystalloid Granuloma of the Parotid Gland

A number of different crystalline structures (crystalloids) can be encountered in neoplastic and non-neoplastic salivary gland lesions, including tyrosine, oxalate, collagenous, intraluminal, and α-amylase crystalloids. While many crystalloids are nonspecific, α-amylase crystalloids have only been r...

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Published inEar, nose, & throat journal Vol. 100; no. 7; pp. 552 - 555
Main Authors O’Malley, Quinn F., Sims, John R., Spaulding, Sarah L., Sandler, Mykayla L., Everest, Sedef, Khorsandi, Azita S., Brandwein-Weber, Margaret, Urken, Mark L.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.08.2021
SAGE PUBLICATIONS, INC
Subjects
Case reports
Exocrine glands
Granulomas
Maxillofacial surgery
Medical diagnosis
Otolaryngology
Tumors
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Summary:A number of different crystalline structures (crystalloids) can be encountered in neoplastic and non-neoplastic salivary gland lesions, including tyrosine, oxalate, collagenous, intraluminal, and α-amylase crystalloids. While many crystalloids are nonspecific, α-amylase crystalloids have only been reported in benign lesions, and their identification may be helpful in distinguishing benign from malignant lesions.1 Although these crystalloids are found in a variety of benign salivary gland tumors, they only rarely induce a granulomatous reaction, resulting in a condition known as “crystalloid granuloma” (CG). We present a case of CG in the parotid gland, misdiagnosed on cytopathology and subsequently surgically resected.
Bibliography:ObjectType-Case Study-2
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ISSN:0145-5613
1942-7522
DOI:10.1177/0145561319871239