Supramolecular linear coordination polymers of human serum albumin and haemoglobin

We describe the synthesis, structure, and functionalities of water-soluble linear coordination polymers of human serum albumin and haemoglobin, which are connected via a bis(terpyridyl)-Fe 2+ complex. These protein fibres were self-assembled by lyophilisation and were transformed into single-wall na...

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Published inChemical communications (Cambridge, England) Vol. 56; no. 99; pp. 15585 - 15588
Main Authors Adachi, Ryo, Suzuki, Shun, Mitsuda, Tatsuya, Morita, Yoshitsugu, Komatsu, Teruyuki
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 25.12.2020
Subjects
Absorption spectra
Coordination polymers
Hemoglobin
Iron chlorides
Long fibers
Mass spectra
Nanofibers
Proteins
Self-assembly
Serum albumin
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Summary:We describe the synthesis, structure, and functionalities of water-soluble linear coordination polymers of human serum albumin and haemoglobin, which are connected via a bis(terpyridyl)-Fe 2+ complex. These protein fibres were self-assembled by lyophilisation and were transformed into single-wall nanotubes. The biological activities of the protein units were perfectly preserved in the long fibres. Human serum albumin and human haemoglobin having two-terpyridyl arms were readily polymerized via a bis(terpyridyl)-Fe 2+ complex to generate watersoluble, uniform, and linear nanofibres.
Bibliography:2
nanofibres. See DOI
nanofibres, Lineweaver-Burk plots of enzyme reaction by [HSA(Tpy
in Hb(Tpy
2+
Electronic supplementary information (ESI) available: Experimental section, UV-vis absorption spectra, MALDI-TOF mass spectra, CD spectra and GFC profiles of protein monomers and protein nanofibres, UV-vis absorption spectral changes upon addition of FeCl
10.1039/d0cc07167f
]
solution, SEM images of various forms of [HSA(Tpy
n
Fe
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc07167f