Recent advances in palladium-catalyzed C(sp)/C(sp)-H bond functionalizations: access to C-branched glycosides

Over the recent decades, tremendous interest has developed in the transformation of complex substrates by C-H activation and functionalization. In particular, palladium-catalyzed directing and non-directing group-assisted C-H functionalization has emerged as a powerful avenue to access C-branched gl...

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Published inOrganic & biomolecular chemistry Vol. 2; no. 2; pp. 264 - 281
Main Authors Azeem, Zanjila, Mandal, Pintu Kumar
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 05.01.2022
Subjects
Carbohydrates
Complexity
Glycosides
Hydrogen bonds
Palladium
Substrates
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Summary:Over the recent decades, tremendous interest has developed in the transformation of complex substrates by C-H activation and functionalization. In particular, palladium-catalyzed directing and non-directing group-assisted C-H functionalization has emerged as a powerful avenue to access C-branched glycosides. Due to the extreme complexity, delicate functionalities, and high stability of C-H bonds, site-selective functionalization of carbohydrate under mild conditions is highly desirable. The purpose of this review is to cover most of the recent advances in palladium-catalyzed C(sp 3 ) and C(sp 2 )-H bond functionalizations for the synthesis of C-branched glycosides along with future directions. This review summarises recent developments in palladium-catalyzed directed and nondirected C-H functionalization approaches to access C-branched aryl/alkenyl/alkyl glycosides with reaction characteristics and proposed mechanisms.
Bibliography:Zanjila Azeem obtained her M.Sc in 2018 and received her inspire award and gold medal from P.P.N. PG college. After qualifying for CSIR-JRF, she is currently pursuing her PhD under Dr. Pintu Kumar Mandal. Her research focuses on stereoselective glycosylation and C-H functionalization.
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glycosides and catalytic stereoselective glycosylation.
Pintu K. Mandal obtained his Ph.D. in 2009 at the Jadavpur University, Kolkata. He pursued his postdoctoral research in the laboratory of Professor W. Bruce Turnbull at the University of Leeds, Leeds. He was selected as a Newton International Fellow (RSC, 2009-2011) at the University of Leeds, UK. Then, he moved to Georgia State University, Atlanta, USA to work with Professor Peng George Wang. He returned to India in May 2013 and held a Scientist position; he currently holds the positions of Principal Scientist at CSIR-CDRI, Lucknow and Associate Prof. at the AcSIR, New Delhi. His research interests include the efficient chemical synthesis of biologically relevant
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ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob02142g