In Vitro Release of Local Anaesthetic and Anti-Inflammatory Drugs from Crosslinked Collagen Based Device
The drug delivery systems that are the object of this article take the form of a hydrophilic matrix (collagen or crosslinked collagen) containing a drug. These devices can be used as The model active agents, were chosen from the range of local anaesthetics (lidocaine hydrochloride), anti-inflammator...
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Published in | Journal of macromolecular science. Part A, Pure and applied chemistry Vol. 49; no. 9; pp. 699 - 705 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Colchester
Taylor & Francis Group
01.09.2012
Taylor & Francis |
Subjects | |
Online Access | Get full text |
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Summary: | The drug delivery systems that are the object of this article take the form of a hydrophilic matrix (collagen or crosslinked collagen) containing a drug. These devices can be used as The model active agents, were chosen from the range of local anaesthetics (lidocaine hydrochloride), anti-inflammatory (diclofenac sodium salt) and antioxydant (caffeic acid). Whatever the drug affinity for water, in the first time of the experiments, the release appears to be systematically delayed when the matrix is crosslinked. For lidocaine hydrochloride based systems, as the amount of drug increases in the matrix, the high gap concentration between the matrix and the buffer solution promote the diffusion and a Fickian behavior is observed on the release curves. Depending on the chemical nature of the drug and its solubility, several interactions between the drug and the collagen matrix can be considered. A new drug delivery system containing caffeic acid as the anti-inflammatory and antioxydant molecule could be tested. This new system was able to release 95% of the drug in 5 h and the global release rate depends on the initial drug concentration in the device. |
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ISSN: | 1060-1325 1520-5738 |
DOI: | 10.1080/10601325.2012.703491 |